Leading to hypotheses related to their physiological role in the alga that are beingĭr. When used in pull-down assays, they picked up different interactors, Six ferredoxins in the bacterium Escherichia coli, which allowed them to purify each protein and biochemically/biophysically characterizeĮach of them. Redox electron mediator ferredoxin in algal metabolism. Ghirardi’s work involves a systems biology study of the role of the In the search for the best alternative fuel of the future.Ĭurrently, Dr. The observation helped bump up algae as major players ![]() She also reported that algae can produceĭramatically more hydrogen via the sun when the gas-phase to liquid-phase volume ratio H 2-producing capability, and made improvements in hydrogen photoproduction resultingįrom both physical and genetic manipulations. Ghirardi developed a new selection method to isolate algal mutants with improved This approach is now extensively used by groups in Europe to engineer oxygen tolerance Two access pathways for O 2 to the catalytic site of the enzyme. Simulations of O 2 and H 2 gas diffusion through the hydrogenase enzyme, which led to the identification of They also initiated the use of molecular dynamics to create computational The assembly of -hydrogenases, which led to the development of a bacterial systemįor production of large quantities of active algal hydrogenase enzyme, a major breakthrough In addition, her team identified three enzymes required for Ghirardi co-discovered a sulfur-deprivation process, which allows sustained hydrogen Metabolic, biochemical, and genetic aspects of algal metabolism.ĭr. ![]() Ghirardi's work at NREL involves photobiological hydrogen production and covers She is involved in both basic and applied research and has had extensiveĮxperience working with photosynthetic organisms.ĭr. Invalid email entered: Maria Ghirardi is a principal scientist at NREL, a research associate professorĪt the Colorado School of Mines, and a Renewable and Sustainable Energy Institute
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